Skin & soft tissue, resp tract infections. Bone & joint indication eg, osteomyelitis, septic arthritis, prophylaxis in bone & joint surgery. Septicemia, endocarditis, CNS infections, staph enterocolitis & cystitis.
Dosage/Direction for Use
250 mg IM 4-6 hrly. 500 mg by slow IV inj over 3-4 mins, 4-6 hrly or by IV infusion. Childn 2-10 yr ½ of the adult dose, up to 2 yr ¼ of the adult dose. Childn 12.5-25 mg/kg qid.
Contraindications
Hypersensitivity to penicillins.
Drug Interactions
Erythromycin, gentamicin, kanamycin, colistin, oxytetracycline, chlorpromazine, vit C, tetracycline & polymixin B. IV lipids, blood products & protein hydrolysates or other proteinaceous fluids. Chloramphenicol & tetracyclines may antagonize bactericidal effect in vitro. Probenecid increases serum peak plasma conc & prolongs serum conc of cloxacillin.
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